Su Ryon Shin, Ph.D.
Instructor, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
shin.lotus@gmail.com; sshin4@bwh.harvard.edu
Biography:
Dr. Shin is one of the innovative and productive young faculties in regenerative medicine and biomedical engineering, with a growing international reputation for her accomplishments. Dr. Shin fully committed to address this major challenge head-on by using an interdisciplinary approach at the interface between tissue engineering, biomaterials, nanomaterials, biosensor, bioactuator, bioprinting, and organ-on-a-chip. Dr. Shin’s research focuses on developing micro- and nanoscale technologies to control and monitor cellular behavior with particular emphasis in developing microscale biomaterials and engineering systems for biomedical applications. She has been developing multifunctional cardiac scaffolds and 3D biohybrid actuator using biocompatible hydrogel for both therapeutic purposes and in vitro studies. Her team currently focuses on developing bioprinting technology to control cellular behavior, as well as regulating cell alignment within engineered systems. Also, Dr. Shin has been developing and testing of integrated organs-on-chip systems with built-in biosensors. Dr. Shin is one of the most productive and prolific young innovators in the country. During my research period at the Brigham, Dr. Shin has been extremely prolific in my work, which has resulted in several funded grants by DOD-Advanced Regenerative Manufacturing Institute, Air Force Office of Sponsored Research, Qatar University, and Toyota Company. In addition, she has published over 87 papers in peer-reviewed journals such as PNAS, Advanced Materials, ACS Nano, Angewandte Chemie, etc. Her H index, which is a measure of scientific productivity, is already at 35. In just a few years she has been cited over 3,690 times. Dr. Shin is a 2015 and 2018 recipient of a BWH Stepping Strong Innovator Award.
Topic title：Micro/nano engineered biomaterials for manufacturing
biomimetic tissues and biomedical applications
Abstract ：Engineered biomaterials have recently drawn a lot
of attention for applications in various biomedical fields of research due to
their high biocompatibility and similarity to a native extracellular matrix
(ECM). To increase the utilization of biomaterials in these areas, composite or
hybrid biomaterials incorporating nanomaterials and bioactive molecules have
been developed to adjust the biological and physical properties of the biomaterials
to resemble native tissues and to bring controlled release of biological
compounds (e.g. drug and genes) to adapt to the criteria required for their
specific applications. Also, the intricate heterogeneity in biological
structures and the physical properties of native tissues/organs
has intrigued a need for multi-material and multi-cellular hybrid designs. Therefore,
advances in biomanufacturing techniques which can manipulate the structure of
the engineered biomaterials were developed to recapitulate biological systems with
adequate levels of functionality for tissue/organ remodeling and regeneration.
Furthermore, to bring advanced functions such as the controlled release of drugs
and the replication of organ functions, such as the sensory function of the nose,
biocompatible electronic devices and biosensing platforms have been integrated into
biomanufactured tissue constructs. Therefore, the hybrid system could be useful
for creating multifunctional tissue/organ and biohybrid actuators for both
therapeutic purposes and in vitro studies. The engineered 3D tissue constructs can be used for toxicity assays
based on organs-on-a-chip platforms, which have become increasingly important
for drug discovery.
