Kaiming Ye, Ph.D.
Professor, Department of Biomedical Engineering,
Binghamton University
kye@binghamton.edu
Biography:
Dr. Kaiming Ye is Professor and Department Chair of Biomedical Engineering and Director of Center of Biomanufacturing for Regenerative Medicine at Binghamton University (BU), State University of New York (SUNY). He is one of the top most distinguished and accomplished leaders in the field of Medical and Biological Engineering. He is fellow of AIMBE and senior member of IEEE. His scholarly contributions to the field include the development of the concept of advanced biomanufacturing and his leadership role in promoting and growing the field. He organized and co-organized more than 10 conferences and workshops as well as two WTEC studies including Global Assessment of Stem Cell Science and Engineering and Global Assessment of Advanced Biomanufacturing. He is well-known for his work in bioprinting and human pancreatic organoid development from stem cells. He has invented fluorescent nanosensors for continuous glucose monitoring. His work in advanced biomanufacturing was featured as a cover story of ASEE PRISM. His work in glucose sensors was featured in the Pittsburgh Post-Gazette. He has delivered keynote/plenary speech in numerous international and national conferences. He serves as Associate Editor, and member of Editorial Boards of 13 journals. He is also a highly accomplished administrator and has contributed significantly to national policy-make in science and engineering. During his tenure at NSF, he directed a biomedical engineering program, making funding decisions and implementing post-award management. He was a member of a number of interagency working groups, including the Interagency Workgroup for Neuroscience under the Office of Science and Technology Policy (OSTP), Interagency Modeling and Analysis Workgroup, and Multiagency Tissue Engineering and Regenerative Medicine Workgroup. Finally, he is a highly accomplished educator in biomedical engineering. As chair of Biomedical Engineering Department at BU, he led the growth of the Department.
Topic title：Formulating Bioinks for Tissue Biofabrication
Abstract：3D bioprinting enables creating tissue constructs with heterogeneous compositions and complex architectures. One of the great challenges in realizing this technology is to develop printable biomaterials for creating biologically functional tissues. In this study, we formulated a new type of bioink and used it for printing small diameter tissue engineered vessel grafts (TEVGs). By incorporating fibrinogen with gelatin to leverage their favorable rheological properties and printability, we fabricated TECGs whose biomechanical properties improve over time. We discovered that the blending of a heat-treated gelatin with fibrinogen bestows desired shear-thinning properties to the fibrinogen, and makes it amenable to extrusion bioprinting. We found that the heat-treatment of gelatin remarkably affects the rheological properties of the blend bioinks, which in turn influences the printability of gelatin-fibrinogen blends. We observed that not only concentration of gelatin but the heat treatment also affects cell viability during extrusion. The bioink’s cell concentration also influences the printability of the inks. We found that more evenly distributed vascular constructs can be achieved with lower concentrations of enzyme during crosslinking. Finally, we determined the printed vascular constructs were able to develop into small-diameter vascular grafts. We observed increased collagen deposition during two months of culture. The burst pressure of the constructs reached 1,110 mmHg, which is about 52% of the value of the human saphenous vein. An analysis of the tensile mechanical properties revealed that both the circumferential and axial elastic moduli increased over time. This innovative approach can be used to formulate many different bioinks for tissue biofabrication.
