Topic title:AdvancedFabrication and Measurement Methods for Organ-on-a-Chip
Abstract:Organ-on-a-chip(OoC)is a cell-culture microdevice which can simulate tissue/organ physiologicalfunction. As a revolutionary biomedical technology, OoC was named “Top 10 EmergingTechnologies” by Davos Forum in 2016. The construction of OoC needs the cross-fusionof multi-disciplinary fields, such as tissue engineering, materials science,bionics, material processing/forming technology and computer science. In orderto realize the simulation of the physiological parameters such as biomechanics,the chip-body with bionic micro channel and cavity is constructed by 3Dprinting or other processing technology. Scaffolds with specific 3D structure canprovide support and inducing ability for cells’ growth, organization anddifferentiation. Sensors integrated within the OoC can be used to measure thephysical and chemical parameters in-situ. In the foreseeable future, OoC willgradually become an alternative experimental technology to animal experimentsand play an important role in disease model, drug discovery, human enhancement,environmental evaluation and other applications.
[1] F. Zheng, F. Fu, Y. Cheng, C. Wang, Y.Zhao, and Z. Gu, Small 2016, 12, 2253-2282.
[2] Q. Zhong, H. Ding, B. Gao, Z. He, and Z.Gu, Adv. Mater. Technol. 2019, 4, 1800663.
[3] H. Ding, Q. Zhang, H. Gu, X. Liu, L.Sun, M. Gu, and Z. Gu, Adv. Funct. Mater. 2019, 0,1901760.