Haiming Fan, Ph.D.
Professor, College of Chemistry & Materials Science, Division of Life Science & Medicine,
Northwest Univerisity
fanhm@nwu.edu.cn
Biography:
Prof. Haiming Fan received his Ph.D. degree from Institute of Physics, Chinese Academy of Science in 2004. In 2013, he began working as a distinguished professor at Northwest University, Xi’an, China. His major research interests include the design and synthesis of advanced magnetic nanomaterials for bio-imaging and therapy, magnetic manipulation of molecular interaction, cell function and cell fate. Prof. Fan has published more than 90 peer-review papers including J. Am. Chem. Soc., ACS Nano, Adv. Mater, Nano Lett., with the citations over 5200 times.
Topic title：Engineered Magnetic Nanoparticle for Advanced biomedical applications
Abstract：Iron oxide nanoparticles (IONPs) as representative biomagnetic nanoparticle, possessing high biocompatibility and unique magnetic properties, have been widely used for various biomedical applications. In particular, IONPs can mediate multiple bio-related effects under the external magnetic field such as induction local field, induction heat, induction mechanical force and enhanced nanozyme activity at the nanoscale, which allows the real-time, noninvasive visualization or magnetic manipulation of those biological events critical to the major diseases in human. Despite the great advantages of magnetic nanoparticle mediated diagnostics and treatment, these exciting applications has been largely hindered by the poor mediated efficiency of traditional superparamagnetic iron oxide (SPIO) formulations. In this talk, we will introduce our recent work on the magnetism-engineering of IONPs, and their high performance applications in magnetic resonance imaging and magnetothermal treatment. For example, FVIO nanoring possesses a ferrimagnetic vortex domain structure, in which magnetization is circumferential to the ring without stray fields. This unique magnetic structure endows these FVIOs with negligible remanance and coercivity that ont only reduce greatly dipole-dipole interactions and enable a good colloidal stability, but also give rise to much high saturation magnetization and susceptibility in comparison with SPIOs. Under the external field, FVIOs will subject to a transition from vortex state to onion state, showing the superior thermal conversion efficiency with a specific absorption rate (SAR) of ~5000 emu/g. This value is 20-fold larger than that of SPIO, which allow us to realize high-efficient magnetic hyperthermia treatment of tumor, activation of immunological effect, and magnetothermal labelling for single-cell MRI tracking etc. In summary, the development of these engineered iron oxides nanoparticle could significantly improve the mediated efficiency and biological effect of IONPs, which in combination with novel magnetically manipulable techniques shows great potential for future magnetic nanotheranostics.
