Xiaohong Wang

Xiaohong Wang, Ph.D.
Professor, ERC Advanced Investigator Grant Group,
Institute for Physiological Chemistry, 
University Medical Center of 
the Johannes Gutenberg University Mainz 
wang013@uni-mainz.de

Biography: 
Prof. Dr. Xiaohong Wang is a chemist and material scientist. In 2005 she became a professor in inorganic chemistry in China. Since 2006 she has a close collaboration with the group of Prof. W.E.G. Müller and she joined his team in Mainz in 2009. She has a long-standing expertise in the development and characterization of regenerative-active materials and the molecular processes underlying their biological/morphogenetic activity. Her achievements include the elucidation of the mechanism of hardening of biogenetically formed silica and of the enzymatic formation of calcium carbonate “bio-seeds” in bone mineralization. Her scientific work comprises about 300 publications [Hirsch-index: 34; ISI Web of Science]. In addition, she has coordinated/participated, as a PI, in several EU-funded projects, such as Core-Shell, SPECIAL, MarBioTec, BlueGenics or the ongoing H2020-InnovaConcrete. In addition, she is the scientific coordinator of the German-Chinese “Joint Center” on Bioinspired Materials. 

Topic titleContribution of bio-artificial intelligence for the fabrication of biological and bio-functional structures by bio-3D printing applied in tissue engineering
AbstractBiomimetic materials have been gaining increasing importance in tissue engineering since they may provide regenerative alternatives to the use of autologous tissues for transplantation. Recently, we could establish that polyphosphate (polyP) is not only a smart/intelligent biomaterial but also feature highly adaptive behaviors, like pH-dependent nanoparticle- or coacervate formation. Our group also succeeded to prepare polyP in a biomimetic way.

The presently used non-regenerative active, inert metals or ceramics to be applied for the fabrication of implant materials to ameliorate bone defect, have no adaptive potentialities. In contrast polyP comprises this property, a characteristics which is essential to classify polyP as a potential semiconductor materials, acting as signaling conductor, instead of a silicon-based circuits. 

In the experiments presented we applied polyP for bioprinting of a functionalized three-dimensional template, together with N,O-carboxymethyl chitosan (N,O-CMC). This hybrid material mimics the physiological extracellular matrix. Like polyP also N,O-CMC is widely used in tissue engineering. Together with polyP, N,O-CMC elicit functional activity, including also osteogenic potency. The two polymers, N,O-CMC and polyP, are linked together via Ca2+ bridges and has been proven to be printable and durable. The N,O-CMC - polyP printed layers and tissue units retain their properties to induce SaOS-2 bone-like cells to biomineralization. Subsequent in vivo experiments revealed a strong regeneration-inducing activity of the material in the rat calvarial defect model. In turn, N,O-CMC - polyP represents a promising hybrid material useful as a potential custom-designed scaffold for alternative tissue-engineering solutions.

References

1.  Müller WEG, Tolba E, Schröder HC and Wang XH (2015) Macromolec Biosci 15: 1182-1197.

2.  Müller WEG, Tolba E, Schröder HC, Neufurth M, Wang S, Link T, Al-Nawas B and Wang XH (2015) J Mat Chem B 3: 1722-1730.

3.  Neufurth M, Wang XH, Schröder HC, Feng QL, Diehl-Seifert B, Ziebart T, Steffen R, Wang SF and Müller WEG (2014) Biomaterials 35: 8810-8819.

4.  Müller WEG, Wang SF, Ackermann M, Gerich T, Wiens M, Neufurth M, Schröder HC and Wang XH (2019) Adv Funct Mater; https://doi.org/10.1002/adfm.201905220.


Key Dates
Key Dates
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Deadline for Submission of Abstract:

October 31, 2019

Notification of abstract acceptance:
November 15, 2019




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