Xiaohong Wang, Ph.D.
Professor, ERC Advanced Investigator Grant Group,
Institute for Physiological Chemistry,
University Medical Center of
the Johannes Gutenberg University Mainz
wang013@uni-mainz.de
Biography:
Prof. Dr. Xiaohong Wang is a chemist and material scientist. In 2005 she became a professor in inorganic chemistry in China. Since 2006 she has a close collaboration with the group of Prof. W.E.G. Müller and she joined his team in Mainz in 2009. She has a long-standing expertise in the development and characterization of regenerative-active materials and the molecular processes underlying their biological/morphogenetic activity. Her achievements include the elucidation of the mechanism of hardening of biogenetically formed silica and of the enzymatic formation of calcium carbonate “bio-seeds” in bone mineralization. Her scientific work comprises about 300 publications [Hirsch-index: 34; ISI Web of Science]. In addition, she has coordinated/participated, as a PI, in several EU-funded projects, such as Core-Shell, SPECIAL, MarBioTec, BlueGenics or the ongoing H2020-InnovaConcrete. In addition, she is the scientific coordinator of the German-Chinese “Joint Center” on Bioinspired Materials.
Topic title:Contribution
of bio-artificial intelligence for the fabrication of biological and
bio-functional structures by bio-3D printing applied in tissue engineering
Abstract:Biomimetic
materials have been gaining increasing importance in tissue engineering since
they may provide regenerative alternatives to the use of autologous tissues for
transplantation. Recently, we could establish that polyphosphate (polyP)
is not only a smart/intelligent
biomaterial but also feature highly adaptive behaviors, like pH-dependent
nanoparticle- or coacervate formation. Our
group also succeeded to prepare polyP in a biomimetic way.
The presently used non-regenerative active, inert
metals or ceramics to be applied for the fabrication of implant materials to
ameliorate bone defect, have no adaptive potentialities. In contrast polyP comprises this property, a characteristics
which is essential to classify polyP as a
potential semiconductor materials, acting as signaling conductor, instead of a
silicon-based circuits.
In the experiments presented
we applied polyP for bioprinting
of a functionalized three-dimensional template, together with N,O-carboxymethyl
chitosan (N,O-CMC). This hybrid material mimics the physiological extracellular
matrix. Like polyP also N,O-CMC is widely used in tissue engineering. Together with polyP, N,O-CMC elicit functional activity, including also osteogenic potency. The two
polymers, N,O-CMC and polyP, are linked together via Ca2+ bridges
and has been proven to be printable and durable. The N,O-CMC - polyP printed
layers and tissue units retain their properties to induce SaOS-2 bone-like
cells to biomineralization. Subsequent in vivo experiments revealed a strong
regeneration-inducing activity of the material in the rat calvarial defect
model. In turn, N,O-CMC - polyP represents a promising hybrid material useful
as a potential custom-designed scaffold for alternative tissue-engineering
solutions.
References
1. Müller WEG, Tolba E, Schröder
HC and Wang XH (2015) Macromolec Biosci 15: 1182-1197.
2. Müller WEG, Tolba E, Schröder HC, Neufurth M, Wang S, Link T,
Al-Nawas B and Wang XH (2015) J Mat Chem B 3: 1722-1730.
3. Neufurth M, Wang XH, Schröder HC, Feng QL, Diehl-Seifert B, Ziebart
T, Steffen R, Wang SF and Müller WEG (2014) Biomaterials 35: 8810-8819.
4. Müller WEG, Wang SF,
Ackermann M, Gerich T, Wiens M, Neufurth M, Schröder HC and Wang XH (2019) Adv
Funct Mater; https://doi.org/10.1002/adfm.201905220.