Daishun Ling, Ph.D.
Professor, College of Pharmaceutical Science,
Zhejiang University
Biography:
Daishun Ling, Principal investigator and Professor of the College of Pharmaceutical Science, Zhejiang University. Prof. Daishun Ling received his Ph.D. (2013) in School of Chemical and Biological Engineering from Seoul National University. Later, he worked as a senior researcher at the Center for Nanoparticle Research, Institute for Basic Science. Since joined the faculty of College of Pharmaceutical Sciences at Zhejiang University in 2014 through “Zhejiang University 100 Talent Professor”, he has been focusing on the dynamic assembly/disassembly of functional nanoparticles, stimuli-responsive nanomedicines, designed synthesis and surface engineering of functional nanomaterials for biomedical applications. Up to now, he has published > 70 papers in prominent international journals such as Nat. Mater., Nat. Biomed. Eng., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., ACS Nano, Adv. Funct. Mater., Nano Lett., ACS Cent. Sci., Biomaterials, Small, etc. He has been serving as Board Member of Science Bulletin, Youth Editorial Board Member of Acta Pharm. Sin. B and Chinese Chem. Lett.. He has received several prestigious fellowships and awards including the National 1000 Plan for Young Talents, the National Science Found for Excellent Youth Scholars, and the National Key Research and Development Program for Young Scientist.
Topic title：Dynamic Superparticles For Biomedical Applications
Abstract：Nanotechnology has received significant attention recently because of its important role in biomedical research. The materials consisting of the nanoparticles produce fascinating and various functionalities [1-3]. The controllable assembly mediated by a multitude of smart ligands would lead to the flexible modulation of nanomaterials’ fate in vivo [4-7]. The clever fabrication of dynamic superparticles via the ligands directed nanoparticle self-assemblies would lead to developing multifunctional nano-biomedical platforms for simultaneous targeted delivery, fast diagnosis, and efficient therapy [8,9]. Furthermore, the ingenious control over the assembly/disassembly process based on small-sized inorganic nanoparticles could achieve both in vivo targeted delivery and subsequent excretion caused by environmental stimuli-responsive disassembly [10].
References
[1] Q. Weng, X. Hu, J. Zheng, F. Xia, N. Wang, H. Liao, Y. Liu, D. Kim, J. Liu, F. Li, Q. He, B. Yang, C. Chen, T. Hyeon, D. Ling, Toxicological risk assessments of iron oxide nanocluster- and gadolinium- based T1MRI contrast agents in renal failure rats, ACS Nano 13 (2019) 6801-6812.
[2] H. Wu, F. Li, W. Shao, J. Gao, D. Ling, Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel, ACS Cent. Sci. 5 (2019) 477-485.
[3] Q. Chen, Y. Du, K. Zhang, Z. Liang, J. Li, H. Yu, R. Ren, J. Feng, Z. Jin, F. Li, J. Sun, M. Zhou, Q. He, X. Sun, H. Zhang, M. Tian, D. Ling, Tau-targeted multifunctional nanocomposite for combinational therapy of Alzheimer's disease, ACS Nano 12 (2018) 1321-1338.
[4] F. Li, Z. Liang, J. Liu, J. Sun, X. Hu, M. Zhao, J. Liu, R. Bai, D. Kim, X. Sun, T. Hyeon, D. Ling, Dynamically reversible iron oxide nanoparticle assemblies for targeted amplification of T1-weighted magnetic resonance imaging of tumors, Nano Lett. 19 (2019) 4213-4220.
[5] F. Li, Y. Du, J. Liu, H. Sun, J. Wang, R. Li, D. Kim, T. Hyeon, D. Ling, Responsive assembly of upconversion nanoparticles for pH-activated and near-infrared-triggered photodynamic therapy of deep tumors, Adv. Mater. 30 (2018) 1802808.
[6] J. Lu, J. Sun, F. Li, J. Wang, J. Liu, D. Kim, C. Fan, T. Hyeon, D. Ling, Highly sensitive diagnosis of small hepatocellular carcinoma using pH-responsive iron oxide nanocluster assemblies, J. Am. Chem. Soc. 140 (2018) 10071-10074.
[7] F. Li, J. Lu, X. Kong, T. Hyeon, D. Ling, Dynamic nanoparticle assemblies for biomedical applications, Adv. Mater. 29 (2017) 1605897.
[8] T. Zhang, F. Li, Q. Xu, Q. Wang, X. Jiang, Z. Liang, H. Liao, X. Kong, J. Liu, H. Wu, D. Zhang, C. An, L. Dong, Y. Lu, H. Cao, D. Kim, J. Sun, T. Hyeon, J. Gao, D. Ling, Ferrimagnetic nanochains-based mesenchymal stem cell engineering for highly efficient post-stroke recovery, Adv. Funct. Mater. 29 (2019) 1900603.
[9] J. Wu, F. Li, X. Hu, J. Lu, X. Sun, J. Gao, D. Ling, Responsive assembly of silver nanoclusters with a biofilm locally amplified bactericidal effect to enhance treatments against multi-drug-resistant bacterial infections, ACS Cent. Sci. 5 (2019) 1366-1376.
[10] X. Hu, J. Sun, F. Li, R. Li, J. Wu, J. He, N. Wang, J. Liu, S. Wang, F. Zhou, X. Sun, D. Kim, T. Hyeon, D. Ling, Renal-clearable hollow bismuth subcarbonate nanotubes for tumor targeted computed tomography imaging and chemoradiotherapy, Nano Lett. 18 (2018) 1196-1204.