Maling Gou, Ph.D.
Professor, State Key Laboratory of Biotherapy, West China Hospital,
Sichuan University
goumaling@scu.edu.cn
Biography:
Maling Gou is a professor at State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. His research is focused on 3D printing and nanotechnology enabled or improved advanced treatments for cancers and nerve injury. He has published more than 100 peer-reviewed papers in the international journals, such as Nature Commun, Adv Funct Mater, ACS Nano, Adv Sci, Nanoscale, Adv Drug Deliver Rev. H-index has been above 30. In the meantime, he is the vice-president of Sichuan Association for Additive Manufacturing, China and editorial members of more than 5 international journals. As well, he holds over 10 National Invention Patents, some of them have been transferred to pharmaceutical companies for further development. In 2014, he wined National Outstanding Youth Science Foundation.
Topic title：DLP-based 3D printing
technology for drug delivery and therapy
Abstract：Digital light processing (DLP) based 3D-printing technology is an additive manufacturing technology based on projection light, has been widely applied in the field of drug delivery and therapy. Compared to other printing technologies, it contributes in the minimisation of fabrication time and complexity of the production structures, leading to more effective targeted-release and customized drug delivery systems. In our studies, we have fabricated injectable hydrogels, nerve conduits and conformal Implant for postsurgery residual cavity, to realize more effective and targeted drug delivery and therapy. Injectable microgels is a critical tool in drug delivery. Recently, it is limited in rapid and cost-effective fabrication of customized microgels. We have DLP-printed microgels mixing nanoparticle-encapsulated drugs with tailored shapes and sizes for sustained drug release. Also, it is demonstrated that cells can be also printed into microgels with survival and proliferation. In addition, the 3D printed nerve conduit containing polymeric nanoparticles can sustained release RGFP966 to promote the remyelination of Schwann cells by activating PI3K–AKT–ERK signal pathwaym which could efficiently repair the injured nerves and inspire the development of future functional nerve conduits. Meanwhile, a 3D-engineered conformal implant for eradicating the postsurgery residual glioblastoma is also designed. This implant can match the tumor cavity and release an oncolytic virus-inspired DNA nanocomplex to kill glioblastoma cells through apoptosis induction, which significantly prolongs overall survival.