Yong He, Ph.D.
Professor, School of Mechanical Engineering
Zhejiang University
yongqin@zju.edu.cn
Biography:
Yong He obtained his BSc in engineering mechanics, at the China University of Mining and Technology in July 2001. In March 2008 he obtained his Ph.D. degree in mechanical engineering at the Zhejiang University. He is currently a full professor at Zhejiang University, School of Mechanical Engineering. In 2016, he was honored the excellent young scholar of China by NSFC for his work in 3D bioprinting (Only ten persons per year in Mechanical Engineering). Also he is the deputy director of Key Lab of 3D Printing Process and Equipment of Zhejiang Province. His research is focused on the 3D bioprinting, development of organs on chips and microfluidic analytical devices. Now he has published more than 70 papers and authorized above 40 patents, with an H index of 25.
Topic title：3D Bioprinting：from Minispheroids to Large-scale Constructs
Abstract：This report reviews the research progress of our group in the past two years. We have developed a series of desk-top 3D bioprinter, including extrusion-based bioprinter (EFL-BP6601) which was positioned to lower the use threshold to make the bioprinter work better, photocuring-based 3D bioprinting (EFL-BP8600) which could ensure the batch of the printed hydrogel structures consistent with resolution of 40um, electrohydrodynamic 3D printer (EFL-BP5800) which can fabricate high-resolution scaffolds with ultrafine fibers (3-20 μm). Besides, we have mass-produced a series of photocurable bioink (EFL-GM), such as GelMA、HAMA、CSMA. Based on the developed bioprinter and bioink, serials of novel bioprinting methods were developed to fabricate GelMA-based cell-laden structures from minispheroids to lager-scale constructs. Electro-assisted bioprinting was presented to print low-concentration GelMA microdroplets with high efficiency, and airflow-assisted bioprinting was presented to build heterogeneous organoids in microspheres with excellent resolution and spatial organization. Coaxial bioprinting was presented to fabricate morphology controllable GelMA microfibers and it has been preliminarily demonstrated that cell-laden fiber can become a standard-use product like woundplast. Two-step crosslinking bioprinting was presented to fabricate complex GelMA-based scaffolds with high shape fidelity by using nanoclay as support, and digital light processing bioprinting was systematically studied to fabricate complex GelMA-based scaffolds with high resolution. The recent work of our group might give some thoughts to better realize transition from bionic manufacturing of organizational structure to functional reconstruction of 3D bioprinting.
